Guillermo Morales-Ortega, Estíbaliz Merino, Javier Carreras*
We report a simple protocol for the transformation of Csp3–Csp3 to Csp3–N in homobenzylic sulfonamides in combination with N-iodoimides to form gem-diamino derivatives. The reaction exhibits a wide functional group tolerance and allows the incorporation of bioactive-derived fragments. The mechanistic insights provided by control experiments and DFT calculations suggest that an imine intermediate is formed after C–C bond cleavage.
Chem. Sci. 2025, doi: 10.1039/D5SC02168E