Víctor Rojas, Javier Carreras, Alberto Avenoza, Jesús H. Busto, and Jesús M. Peregrina
A new synthetic strategy for nitrogen heterocycles was developed that incorporates fused-ring systems and takes advantage of a stereodefined ring-rearrangement metathesis process of substituted 7-azanorbornenes as the stereocontrolled key step. A set of new 1-azabicyclo[n.3.0]alkenones (n = 3, 4, and 5) that include new analogues of pyrrolam were prepared by using this methodology.
Eur. J. Org. Chem. 2023, 3817; doi: 10.1002/ejoc.201300126