Ricarda Miller, Javier Carreras, Michael E. Muratore, Morgane Gaydou, Francesco Camponovo, and Antonio M. Echavarren
A practical aminocyclization of 1,6-enynes with a wide variety of substituted anilines, including N-alkyl anilines, has been achived by using cationic [JohnPhosAu(MeCN)]SbF6 as a general purpose catalyst. The resulting adducts can be easily converted into polycyclic compounds by palladium- and gold-catalyzed reactions.
J. Org. Chem. 2016, 81, 5, 1839–1849; doi: 10.1021/acs.joc.5b02607