Javier Carreras, Yanay Popowski, Ana Caballero, Elizabeth Amir and Pedro J. Pérez
The selective catalytic functionalization of the C–H bond of azulene upon incorporation of carbene or nitrene units with metal-based catalysts is described. Ethyl diazoacetate or ArI═NTs are employed as carbene or nitrene precursors, respectively. The azulene derivatives are subsequently employed as building blocks toward more complex structures with potential use as biodegradable materials.
J. Org. Chem. 2018, 83, 11125; doi: 10.1021/acs.joc.8b01731