J. Carreras, A. Avenoza, J. H. Busto, and J. M. Peregrina
In this paper we describe a highly regioselective ring-opening metathesis−cross metathesis (ROM−CM) process between methyl N-Boc-7-azabicyclo[2.2.1]hept-2-en-1-carboxylate, a bridgehead-substituted 7-azanorbornene system, and electron-poor olefins. The reaction opens the way to the synthesis of interesting α-amino diacids and pyrrolizinone derivatives that incorporate quaternary stereocenters.
Org. Lett. 2007, 9, 1235; doi: 10.1021/ol06310516